课题组的研究方向为医学物理、成像算法。

主要研究内容包括：精确定量PET和SPECT成像、PET和SPECT成像系统的设计和蒙特卡洛模拟、计算机图像重建和GPU加速、定量成像过程中的物理效应校正、药代动力学成像等。

2022：Ones to Watch, Society of Nuclear Medicine and Molecular Imaging (SNMMI)

2020:   Scientific Session Young Investigator Competition Finalist, American Society of Nuclear Cardiology (ASNC) Annual Meeting 

2019:   Physics, Instrumentation and Data Science Young Investigator Award Honorable Mention, Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting

2019:   Alavi–Mandell Award for the publication entitled “Simplified Quantification and Acquisition Protocol of 123I-mIBG Dynamic SPECT”

2017:   Alavi–Mandell Award for the publication entitled “Quantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction Method”

代表论文

Hu H, Liang Z-W, Zhao Y-B, Liu H*, Dai T-T, Wei Q-Y, Jiao F, Hang Z-B, Liu Y-Q, He Z-X*, Wu J*. Comparative Evaluation of Voxel-Level Dosimetry Methods in 90Y-Microsphere Radioembolization Using PET/CT. Molecular Pharmaceutics. 2026;10.1021/acs.molpharmaceut.5c01411.

Zhang D^#, Gu Y^#, Liu H, Ding D, Qin J, Fang W*, Wu J*, Wang L*. Pharmacokinetic modelling of dynamic ^99mTc-4BOH SPECT for myocardial perfusion imaging in patients with coronary artery disease. Journal of Nuclear Cardiology. 2025 Nov 21:102570.

Liu H, Zhang Y, Lyu Z, Cheng L, Gao L, Wu J*, Liu Y. Investigation of a Deep Learning-Based Reconstruction Approach Utilizing Dual-View Projection for Myocardial Perfusion SPECT Imaging. American Journal of Nuclear Medicine and Molecular Imaging. 2025, 15(1):15–27.

Wu J^#, Young BD^#, Liu H, Sadeghi MM, Miller EJ, Liu C*. Parametric FDG positron emission tomography Ki images using dual-time-point imaging data for cardiac sarcoidosis: a proof of concept study. Journal of Nuclear Cardiology. 2025, 46:102121.

Wu J, Liu C. Dedicated Tomographic Single Photon Systems. (Book Chapter). In Handbook of Nuclear Medicine and Molecular Imaging for Physicists: Instrumentation and Imaging Procedures, Volume I. 2022, pp. 315-332. CRC Press.

Wu J^#, Boutagy NE^#, Cai Z, Lin SF, Zheng MQ, Feher A, Stendahl JC, Kapinos M, Gallezot JD, Liu H, Mulnix T, Zhang W, Lindemann M, Teng JK, Miller EJ, Huang Y, Carson RE, Sinusas AJ, Liu C*. Feasibility study of PET dynamic imaging of [18F] DHMT for quantification of reactive oxygen species in the myocardium of large animals. Journal of Nuclear Cardiology. 2022, 29(1): 216-225.

Wu J*, Liu H, Ye Q, Gallezot JD, Naganawa M, Miao T, Lu Y, Chen MK, Esserman DA, Kyriakides TC, Carson RE, Liu C*. Generation of parametric K_i images for FDG PET using two 5-min scans. Medical Physics. 2021, 48(9):5219-5231.

Liu H, Thorn S, Wu J*, Fazzone-Chettiar R, Sandoval V, Miller EJ, Sinusas AJ, Liu YH*. Quantification of myocardial blood flow (MBF) and reserve (MFR) incorporated with a novel segmentation approach: Assessments of quantitative precision and the lower limit of normal MBF and MFR in patients. Journal of Nuclear Cardiology. 2021, 28(4):1236-1248.

Liu H, Wu J*, Lu W, Onofrey JA, Liu YH, Liu C*. Noise reduction with cross-tracer and cross-protocol deep transfer learning for low-dose PET. Physics in Medicine and Biology. 2020, 65(18):185006.

Toczek J^#, Wu J^#, Hillmer AT, Han J, Esterlis I, Cosgrove KP, Liu C, Sadeghi MM*. Accuracy of arterial [¹⁸F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study. Journal of Nuclear Cardiology. 2020, 27(5): 1578-1581.

Wu J*, Liu C*. Recent advances in cardiac SPECT instrumentation and imaging methods. (Topical Review). Physics in Medicine and Biology. 2019, 64(6): 06TR01.

Liu H, Wu J*, Sun JY, Wu TH, Fazzone-Chettiar R, Thorn S, Sinusas AJ, Liu YH*. A robust segmentation method with triple-factor non-negative matrix factorization for myocardial blood flow quantification from dynamic ⁸²Rb positron emission tomography. Medical Physics. 2019, 46(11): 5002-5013.

Wu J, Gallezot JD, Lu Y, Ye Q, Liu H, Esserman DA, Kyriakides TC, Thorn SL, Zonouz TH, Liu YH, Lampert RJ, Sinusas AJ, Carson RE, Liu C*. Simplified quantification and acquisition protocol of ¹²³I-mIBG dynamic SPECT. Journal of Nuclear Medicine. 2018, 59(10):1574-1580.

Boutagy NE^#, Wu J^#, Cai Z, Zhang W, Booth CJ, Pfau D, Mulnix T, Liu Z, Miller EJ, Young LH, Carson RE, Huang Y, Liu C, Sinusas AJ. In vivo reactive oxygen species detection with a novel PET tracer, ¹⁸F-DHMT, allows for early detection of anthracycline-induced cardiotoxicity in rodents. JACC: Basic to Translational Science. 2018, 3(3): 378-390.

Wu J*, Liu H, Zonouz TH, Sandoval VM, Mohy-Ud-Din H, Lampert RJ, Sinusas AJ, Liu C, Liu YH*. A blind deconvolution method incorporated with anatomical-based filtering for partial volume correction: validations with ¹²³I-mIBG cardiac SPECT/CT. Medical Physics. 2017, 44(12): 6435-6446.

Wu J, Lin SF, Gallezot JD, Chan C, Prasad R, Thorn SL, Stacy MR, Huang Y, Zonouz TH, Liu YH, Lampert RJ, Carson RE, Sinusas AJ, Liu C*. Quantitative analysis of dynamic ¹²³I-mIBG SPECT imaging data in healthy humans with a population-based metabolite correction method. Journal of Nuclear Medicine. 2016, 57(8):1226-1232.

Wu J, Liu Y, Ma T*, Wei Q, Wang S, Cheng J. GATE simulation based feasibility studies of in-beam PET monitoring in C-12 beam cancer therapy. Nuclear Science and Techniques. 2010, 21(5): 275-280.